chemokine receptors meaning in English
趋化因子受体
Examples
- The pattern of chemokine receptor polymorphism in healthy and hiv positive chinese adults
研究ccr5在爱滋病带菌者的呈抗原细胞上的表现方式 - The expression of erythrocyte chemokine receptor on peripheral blood red blood cells of patients with psoriasis
红细胞趋化因子受体在寻常型银屑病患者外周血红细胞中的表达及其临床意义 - The extracellular 100pl ( ecl1 ) and ecl2 was linked by disulfide bond to maintenanced the stability of the protein secondary structure . in recent years , we showed that ccr5 as a co - receptor could interact with hiv - 1 infect ion . ccr5 was paid closed attention to since it was cloned in 1996 . the aim is to - obtain the sequence of first extracillular domain of 3 chemokine receptor 5 ( ccr5 ) n - terminal gene fragment with high level expression in e . coli and to prepare its specific antibody f ( ab ' ) ; , and its detected method
Ccr5具有g蛋白偶联受体家族( g - proteincoupledreceptors ， gpcrs )所特有的7个跨膜区( transmembrinedomains ， tm ) ，呈螺旋， tm的氨基酸有很高的保守性，膜外第一襻( extracellularloop1 ， ecl1 )和ecl2之间有二硫键相连，以维持蛋白质二级结构的稳定性。 - Chemotaxis mediated by chemokine receptors , such as cxcr4 , play a key role in lymphocyte homing and hematopoiesis as well as in breast cancer metastasis . we have previously demonstrated that ? - arrestin2 functions to attenuate cxcr4 - meidated g protein activation and to enhance cxcr4 internalization . here we further show that expression of ( - arrestin2 in both hela and hek293 cells significantly enhanced the chemotactic efficacy of stromal - cell derived factor 1 ( ( sdf - 1 ( ) , the specific agonist of cxcr4
- arrestin2是趋化因子受体的一种重要的调节蛋白，本研究工作发现在hek - 293或hela细胞中升高- arrestin2的表达水平会显著增强cxcr4介导的趋化作用，反之当- arrestin2的表达被它的反义核苷酸或rnai所抑制， cxcr4介导的趋化作用则被明显抑制。 - While the suppression of ( - arrestin2 endogenous expression by antisense or rnai technology considerably attenuated sdf - 1 ( - induced cell migration . expression of ( - arrestin2 also augmented chemokine receptor ccr5 - mediated but not egf receptor - mediated chemotaxis , indicating the specific effect of ( - arrestin2
与此相似，另一种趋化因子受体ccr5介导的趋化作用也受- arrestin2的调控，但egf受体介导的趋化作用则不受- arrestin2的调控，说明- arrestin2的作用有一定的受体特异性。